Apoptosis of graft-infiltrating cytotoxic T cells: a mechanism underlying "split tolerance" in mouse liver transplantation.
نویسندگان
چکیده
C57BU10 (BlO; H2b ) mouse liver grafts are accepted in C3R (H2k) recipients without immunosuppressive tberapywhereas skin and heart grafts are rejected acutely.1 However, in vitro mixed leukocyte reactions (MLR) and the generation of cytotoxic T lymphocytes (crL) show the persistence of anti-donor responsiveness.2 The mechanism underlying this "split tolerance" phenomenon is unclear. The present study was undertaken to test the hypothesis that split tolerance might be due to the elimination of effector CfL through apoptosis, while CfL precursors, unsusceptible to apoptosis persist, as shown by the MLR and CfL responses in vitro.
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ورودعنوان ژورنال:
- Transplantation proceedings
دوره 29 1-2 شماره
صفحات -
تاریخ انتشار 1997